Hello Edwin,
i am still fighting this issue (was busy with other things though)...
"Permissions" should not be an issue, the whole implementation is running on a APACHE webserver within a WINDOWS Server 2012 environment (so permissions are not an issue).
Versions: Joomla 3.4.3, JMS 1.3.50basic, Patches 1.3.46
I can confirm that the DNS and APACHE are actually working as expected:
when I upload a simple php-script to the root directory of the JMS installation, I can successfully access this script with the URL of the new slave site.
example:
www3.astronomicalheritage.org/undex.php
when I address the index.php (with the URL of the new slave site) of the same directory (which is defenitly existing), I get the SERVER 500 error in the webserver-access-logfile, but no "error message" in the error-logfile at all!
example:
www3.astronomicalheritage.org/index.php
Other slave sites in this JMS installation are working properly!
I am a little bit "out of ideas" and would appreciate any guidance!
Best regards
Ruediger